Mitochondria split with a calcium hit
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چکیده
منابع مشابه
Mitochondria split with a calcium hit
Egg P bodies protect maternal mRNA P bodies (processing bodies) are cytoplasmic granules that, in somatic cells, store and degrade mRNAs. But P bodies in the worm egg protect mRNA, according to a study by Boag et al. In a separate study Noble et al. observed that worm eggs have different fl avors of P bodies depending on developmental stage. Boag et al. showed that P bodies in eggs lack an mRNA...
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Mitochondria are remarkably dynamic organelles undergoing frequent fusion and fission events. Impairment thereof is linked to numerous neurodegenerative disorders and dysregulation of apoptosis. The principal players mediating mitochondrial fission are considered to be well known and largely conserved between yeast and mammals. However, how the essential fission factor Drp1 is recruited to mito...
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11 Kohn, J., Biochem. J., 65, 9 (1957). 12 Brunelli, B., Arch. Intern. Pharmacodyn., 49, 262 (1935). 13 Szego, C. M., and S. Roberts, Endocrinology, 41, 322 (1947). 14 Westphal, U., J. Am. Oil Chemists' Soc., 41, 481 (1964). 16 Savard, K., W. J. Kolff, and A. C. Corcoran, Endocrinology, 50, 366 (1952). 16 Roberts, S., and C. M. Szego, Endocrinology, 39, 183 (1946). 17 Gardner, L. I., Bull. John...
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Existing theory suggests that mitochondria act as significant, dynamic buffers of cytosolic calcium ([Ca(2+)]i) in heart. These buffers can remove up to one-third of the Ca(2+) that enters the cytosol during the [Ca(2+)]i transients that underlie contractions. However, few quantitative experiments have been presented to test this hypothesis. Here, we investigate the influence of Ca(2+) movement...
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Transport if loaded uclear transporters can be viewed as taxis that move cargo across the nuclear envelope. On page 649, Plafker et al. report that importin-11, a nuclear transport receptor , may be an especially selective cabbie. Importin-11 transports UbcM2, a ubiquitin (Ub)-conjugating enzyme, but it does so only when the enzyme is charged with a Ub at its active site. UbcM2 is an E2 enzyme,...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1823iti4